Table 1.
Small molecule MEK1/2 inhibitors in clinical trials
| Inhibitor | Company | Phase | Status |
|---|---|---|---|
| CI-1040 | Pfizer | Phase II | Development stopped |
| PD0325901 | Pfizer | Phase I/II | Development stopped |
| AZD6244 | Array BioPharma/ AstraZeneca |
Phase II | In progress |
| GDC-0973 | Exelixis/ Genentech |
Phase I | In progress |
| RDEA119 | Ardea Biosciences/ Bayer |
Phase I/II | In progress |
| GSK1120212 | GlaxoSmithKline | Phase I/II | In progress |
| AZD8330 | Array BioPharma/ AstraZeneca |
Phase I | In progress |
| RO5126766 | Hoffmann La Roche | Phase I | In progress |
| RO4987655 | Hoffmann La Roche | Phase I | In progress |
| TAK-733 | Millenium Pharmaceuticals | Phase I | In progress |
| AS703026 | EMD Serono | Phase I | In progress |