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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Prog Retin Eye Res. 2009 Dec 3;29(2):113–134. doi: 10.1016/j.preteyeres.2009.11.004

Figure 5.

Figure 5

Retinal morphology and rhodopsin recovery in rats exposed to light. Dark adapted rats were treated with DMTU (1X IP; 500mg/kg) 30 minutes before the start of light, or at various times thereafter. Light exposures (490–580 nm; ~1200lux) began at 1 am and lasted for 8 hours. The animals were then allowed to recover for 2 weeks in darkness before retinal histology or rhodopsin measurements were made. Retinal histology from the superior hemisphere of rats treated 30 minutes before light (A), 60 minutes after the onset of light (B), or given the saline vehicle (C). Arrow heads denote cone nuclei in the ONL (A) or remnant ONL layer after light damage (B, C). Morphometric measurements of ONL thickness, along the vertical meridian, for rats treated as above (D). Average whole eye rhodopsin levels measured in rats (n=4–5) treated with DMTU at various times before or after light exposure (E). The unexposed controls (open square) and light exposed controls (open triangle) were given an equal volume of saline 30 minutes before exposure. (Adapted from Vaughan et al., Photochem Photobiol. 75: 547–53, 2002 and Organisciak et al., Invest Ophthalmol Vis Sci. 41: 3694–3701, 2000).