Skip to main content
. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Clin Cancer Res. 2010 Feb 23;16(5):1478–1485. doi: 10.1158/1078-0432.CCR-09-1531

Figure 3. Effect of Lestaurtinib in combination with Topo-Cyclo on SY5Y-TrkB xenografts.

Figure 3

Lestaurtinib significantly slowed the growth of SY5Y-TrkB cells growing as xenografts in nude mice compared to vehicle alone, and it significantly enhanced the efficacy of Topo-Cyclo (p< 0.0001, Fig. 3A). Lestaurtinib also significantly improved the EFS of animals treated with either vehicle or Topo-Cyclo alone (p<0.0001, Fig. 3B).