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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Clin Cancer Res. 2010 Feb 23;16(5):1478–1485. doi: 10.1158/1078-0432.CCR-09-1531

Table 1.

Drugs and Doses used for Xenograft Studies

Drug Route Solvent Dose/day this study (literature dose/range) References
Lestaurtinib SQ Vehicle 40 mg/kg (40 mg/kg) Evans AE, 1999 (27)
Cyclophosphamide IP Saline 113 mg/kg; 75 mg/kg (150 mg/kg) Shusterman S, 2001 (33); Houghton PJ, 2007 (28)
Topotecan IP Saline 0.25 mg/kg (0.16-2.0 mg/kg) Zamboni WC, 1998 (35); Thompson J, 1999 (34)
Irinotecan PO Saline 0.63 mg/kg (0.16-2.5 mg/kg) Houghton PJ, 2000 (29)
Temozolomide PO Saline 7.5 mg/kg (14-66 mg/kg) Houghton PJ, 2000 (29)
13-cis-Retinoic Acid IP DMSO 10 mg/kg (10 mg/kg) Ponthan F, 2001 (31)
Fenretinide (4-HPR) IP Saline 120 mg/kg (120 mg/kg) Maurer BJ, 2007 (30)
Bevacizumab IP Saline 5 mg/kg (5 mg/kg) Segerstrom L, 2006 (32)