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Activation of the IP3 enhances the frequency of mEPSCs. (A). Representative sweeps of mEPSCs in the absence or presence of 3-deoxy-3-fluoro-D-myo-inositol 1,4,5-trisphosphate (F-IP3, 50 μM) and F-IP3+AEA (5 μM). (B). Cumulative probability of mEPSC frequency. (C). Mean percentage changes in the frequency of mEPSCs (n=20). (D). Cumulative probability of mEPSC amplitude, and (E). Mean percentage changes in the amplitude of mEPSCs. **P<0.01 compared with baseline. Scale bar: 20pA/2sec
