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. Author manuscript; available in PMC: 2011 Feb 25.
Published in final edited form as: J Med Chem. 2010 Feb 25;53(4):1726–1731. doi: 10.1021/jm901519f

Table 3.

Inhibition of PDE9 and its mutants by inhibitors 1r and 1s

Proteins IC50 (nM) 1s IC50 (nM) 1r
wildtype 88±17 22±3
L420A 607±31 179±17
Y424A 471±19 190±10
F456A 159±9×103 14±2×103
Q453A 50±5×103 9.6±1.3×103
M365A 103±6 46±4
F441A 129±9 43 ± 1
I403A 519±26 200±25