Table 1.
| TABLE 1A. Summary of Cerebral White Matter Pathology in PVL cases | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Case* | GA | PNA | PCA | Focal Acute Necrosis | Focal Organizing Necrosis | Focal Scar w/Mineral | Diffuse Gliosis | ↓WM and/or ↑Vents | Hypo-myelin |
| 1^ 0054 | 35** | 0 | 35 | + | + | + | + | + | − |
| 5^ 9841 | 34** | 0 | 34 | − | + | + | + | − | − |
| 6^ 9636 | 28** | 7 | 35 | + | + | + | + | + | − |
| 7^ 9829 | 36** | 0 | 36 | − | − | + | + | + | − |
| 8 0006 | 39 | 1 | 40 | + | − | − | + | − | − |
| 9 9615 | 35** | 5 | 40 | − | + | − | + | − | − |
| 10 9520 | 36** | 6 | 42 | − | + | + | + | − | + |
| 11 0053 | 40 | 4 | 44 | + | − | − | + | − | − |
| 12 0109 | 28** | 20 | 48 | − | − | + | + | + | + |
| 13^ 9817 | 36** | 15 | 51 | − | + | + | + | + | + |
| 14 9627 | 31** | 64 | 95 | − | + | − | + | + | − |
| TABLE 1B. Continued Summary of the Neuropathology of PVL Cases | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Case* | Bst | CB | BG | Thal | Hipp | CCH | WMH | SAH | GMH | Diagnosis |
| 1^ | − | − | A, B | − | A | − | − | − | − | Potter syndrome; abnormal temporal lobe gyration; malrotation of hippocampi; duplication of dentate gyrus |
| 5^ | − | − | G | G | − | − | − | + | − | Osteogenesis imperfecta |
| 6^ | A | − | E,H | E,H | − | − | + | − | − | Necrotizing enterocolitis; bowel perforation; coagulopathy; sepsis |
| 7^ | A | I | − | − | − | − | − | − | + | CMV infection in utero; ABO incompatibility; dwarfism/skeletal dysplasia; fetal heart failure |
| 8 | − | − | A | − | − | B | − | − | − | Urea cycle defect (ornithine transcarbamylase deficiency); hyperammonemia |
| 9 | NA | J | A | A | A | K | + | − | − | Breech birth; oligohydramnios; renal sclerosis |
| 10 | A | L | A | A | − | A | − | − | − | Intrauterine growth retardation; breech birth; oligohydramnios; dysplastic kidneys; malformed basal ganglia and hippocampus |
| 11 | A | A | NA | A, M | A | − | − | − | − | Congenital cardiac malformation; ECMO treatment |
| 12 | − | − | A | − | − | − | − | − | − | Pulmonary hypertension; pneumonia; ECMO treatment |
| 13^ | − | − | − | N | − | − | − | − | − | Breech birth; oligohydramnios; pneumothorax; respiratory failure |
| 14 | − | − | − | − | A | − | − | + | + | Congenital cardiac malformation; ECMO treatment |
Case numbers are the same as those used in the prior analysis of white matter (15). Cases 2, 3, and 4 from that study were not included here;
Case was included in a previous gray matter survey (3); GA = gestational age in weeks; PNA = postnatal age in weeks; PCA = postconceptional age in weeks; mineral = mineralization; WM = white matter, Vents = ventricles.
Prematurity is defined as a gestational age less than 37 weeks; +, present; −, absent.
Case numbers are the same as those used in the prior analysis of white matter (15) (see Materials and Methods);
Case was included in prior gray matter survey (3); +, pathology present; −, pathology absent; A = reactive gliosis; B = neuronal loss; C = ischemic necrosis; D = hemorrhagic infarct; E = apoptosis; F = focal microhemorrhage; G = mineralization; H = perivascular hemorrhage; I = microglial nodules; J = vermis cortical scar; K = organizing infarct; L = Purkinje cell loss; M = microinfarct; N = necrotic focus in hypothalamus; ECMO = extracorporeal membrane oxygenation; NA = not available; Bst, brainstem; CB, cerebellum; BG, basal ganglia; Thal, thalamus; Hipp, hippocampus; CCH, cerebral cortex hemorrhage; WMH, white matter hemorrhage; GMH, germinal matrix hemorrhage.