Table 3.

Random effects models^* for the association between length-adjusted infant V'maxFRC (natural logarithm of ml/sec as a continuous predictive variable) and pre- and post-bronchodilator lung function at ages 11, 16 and 22 years

	Pre-bronchodilator
	FEV1/FVC Ratio (%)		FEF25-75 (ml/s)		FEV1 (ml)		FVC (ml)
	β (SE)	p	β (SE)	p	β (SE)	p	β (SE)	p
Infant V'maxFRC
(ln of ml/s)	4.7 (1.0)	<0.001	566 (128)	<0.001	168 (64)	0.009	-2.8 (72)	0.9
Age (yr)	-0.4 (0.1)	<0.001	-8.5 (12.7)	0.5	18.2 (6.8)	0.007	41.0 (8.0)	<0.001
Height (cm)	0.1 (0.03)	0.007	51.6 (4.4)	<0.001	45.7 (2.4)	<0.001	49.5 (2.8	<0.001
Weight (kg)	-0.06 (0.02)	0.009	-2.4 (3.0)	0.4	2.5 (1.6)	0.1	6.8 (1.8)	<0.001
Male	-1.9 (1.0)	0.052	140 (129)	0.3	305 (65)	<0.001	464 (72.7)	<0.001
Model Constant	56 (6)	<0.001	-7617 (787)	<0.001	-5653 (408)	<0.001	-5480 (464)	<0.001

	Post-bronchodilator
Infant V'maxFRC
(ln of ml/s)	3.1 (0.8)	<0.001	489 (124)	<0.001	113 (60.1)	0.061	-2.4 (68)	0.9
Age (yr)	-0.2 (0.1)	0.031	17.0 (14.8)	0.2	26.6 (7.0)	<0.001	40.6 (8.0)	<0.001
Height (cm)	0.06 (0.03)	0.048	49.8 (5.1)	<0.001	44.7 (2.4)	<0.001	48.5 (2.8)	<0.001
Weight (kg)	-0.06 (0.02)	0.003	-1.5 (3.2)	0.6	2.5 (1.6)	0.10	6.6 (1.8)	<0.001
Male	-2.1 (0.8)	0.010	42.6 (126)	0.7	312 (61.0)	<0.001	460 (68.9)	<0.001
Model Constant	68 (5)	<0.001	-6943 (821)	<0.001	-5274 (394)	<0.001	-5305 (447)	<0.001

^*Models include 123 individuals with 279 total follow-up spirometry data points. Age, height and weight were entered as time-dependent covariates; infant V'maxFRC and sex as time-independent covariates