Table 1.
The effect of CDU or HET0016 on recovery in left ventricular contractility and vascular haemodynamics of perfused hearts isolated from control animals
| Pmax (mmHg) | LVEDP (mmHg) | CF (ml min−1) | CVR (mmHg ml−1 min−2) | |||||
|---|---|---|---|---|---|---|---|---|
| Groups studied | CON | REP | CON | REP | CON | REP | CON | REP |
| Wistar (C) | 97 ± 5 | 60 ± 4 | 5.5 ± 0.4 | 20.1 ± 2.0 | 12.1 ± 0.4 | 7.2 ± 0.3 | 5.1 ± 0.3 | 18.1 ± 1.4 |
| C + CDU (0.01 μM) | 87 ± 8 | 53 ± 4 | 6.1 ± 0.3 | 22.3 ± 2.0 | 12.2 ± 0.5 | 7.2 ± 1.0 | 5.2 ± 1.0 | 19.2 ± 1.4 |
| C + CDU (0.1 μM) | 99 ± 9 | 62 ± 4 | 6.1 ± 0.3 | 22.2 ± 1.5 | 13.1 ± 0.3 | 8.1 ± 0.4 | 5.2 ± 0.3 | 17.2 ± 1.5 |
| C + CDU (1 μM) | 108 ± 8 | 75 ± 6* | 5.2 ± 0.3 | 16.2 ± 2.0* | 14.1 ± 1.0 | 10.2 ± 0.4* | 4.1 ± 0.2 | 11.1 ± 0.5* |
| C + HET0016 (0.01 μM) | 90 ± 1 | 53 ± 3 | 5.2 ± 0.1 | 20.1 ± 1.0 | 9.2 ± 1.0 | 5.1 ± 0.5 | 5.2 ± 1.0 | 20.3 ± 1.5 |
| C + HET0016 (0.1 μM) | 88 ± 10 | 54 ± 2 | 5.2 ± 0.2 | 19.3 ± 0.5 | 9.2 ± 0.4 | 5.2 ± 0.1 | 5.3 ± 0.5 | 16.1 ± 1.0 |
| C + HET0016 (1 μM) | 95 ± 3 | 51 ± 1 | 6.2 ± 0.4 | 25.2 ± 1.5 | 10.1 ± 1.0 | 6.3 ± 1.0 | 5.1 ± 0.3 | 19.2 ± 1.0 |
| C + CDU (0.1 μM) + HET0016 (0.01 μM) | 97 ± 8 | 62 ± 7 | 5.2 ± 0.3 | 18.1 ± 0.5 | 11.5 ± 0.5 | 7.1 ± 0.5 | 4.3 ± 0.3 | 16.3 ± 1.5 |
The data were computed at 30-min reperfusion (37 °C) and expressed as mean ± SEM.
Pmax, left ventricular developed pressure; LVEDP, left ventricular end-diastolic pressure, CF, coronary flow; CVR, coronary vascular resistance, CON, baseline control; REP, reperfusion.
*
P < 0.05 compared to Wistar controls (C).