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(a) Representative traces showing the vasoconstrictor response (mmHg) to 20-HETE (0.01 nmol) in the perfused mesenteric vascular bed of control (upper panel) and diabetic rats (lower panel) pre-constricted with phenylephrine (PE, 10−6 M). (b) Comparison of 20-HETE-induced vasoconstrictor responses in the perfused mesenteric vascular bed of control and diabetic rats. *Significant difference from control.
