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. Author manuscript; available in PMC: 2010 Mar 3.
Published in final edited form as: Auton Autacoid Pharmacol. 2009 Jan;29(1-2):1–12. doi: 10.1111/j.1474-8673.2009.00426.x

Figure 9.

Figure 9

Panel a. Comparison of the production of 20-HETE in intact renal and mesenteric arteries obtained from diabetic and non-diabetic rats. Vessels were microdissected from the kidney and mesenteric beds of control and diabetic animals and incubated for 1 h in a physiologic salt solution containing 42 μM arachidonic acid and 1 mM NADPH. The vessels were homogenized in the buffer and extracted with ethyl acetate. The products formed were analysed by LC/MS as described in the methods section. Panel b presents the effects of in vitro addition of HET0016 (1 μM) on the production of 20-HETE by intact renal and mesenteric arteries. *Significant difference from the corresponding control value.