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Prompt formation of DSBs where incision in clusters containing bistranded AP sites, of either of the bistranded AP sites is not inhibited. (A) Repair of the AP site after incubation with CHO-K1 nuclear extract. (B) Formation of DSBs: (circle) AP control, (square) AP/AP+5 8-oxoG+1, (diamond) AP/AP−5 8-oxoG−1, (triangle) AP/AP−2 8-oxoG+2, (cross) AP/AP−1 8-oxoG−5. Error bars represent the standard error of the mean from at least three independent experiments.
