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. 2009 Dec 3;38(4):1123–1134. doi: 10.1093/nar/gkp1070

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© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Slow DSB formation in clusters containing bistranded AP sites, when the incision of the AP site in tandem with 8-oxoG confers retardation of incision on the opposing, single AP site. (A) Repair of the AP site after incubation with CHO-K1 nuclear extract: (filled circle) AP control, (filled square) *AP/AP+1 8-oxoG+5, (filled triangle) *AP/AP+2 8-oxoG−2, (open square) AP/*AP+1 8-oxoG+5, (open triangle) AP/*AP+2 8-oxoG−2. The ³²P-labelled strand is denoted by asterisk in each case. (B) Formation of DSBs: (circle) AP control, (square) AP/AP+1 8-oxoG+5, (triangle) AP/AP+2 8-oxoG−2. Error bars represent the standard error of the mean from at least three independent experiments.