Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Dec 6;38(4):1149–1162. doi: 10.1093/nar/gkp1131

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 5. — WRN stimulates pol δ progression through specific FRA16D sequence motifs. (A) Regions 2A, 3A and 4A were synthesized using pol δ + PCNA alone (−) or in combination with WRN (+). All reactions contained 100 fmol template DNA, 2 pmol pol δ and 1 µg PCNA. WRN (100 fmol) was supplemented as indicated. Reactions proceeded for 2, 10 and 30 min. Dashed lines: boundary of CFS insert. (B) Experimental testing for the presence of triplex DNA forming within the poly(dT) tract in regions 3B and 4B. Reactions as described in part A were repeated, except that deaza-dATP was substituted for dATP. Location of microsatelite DNA is indicated.