Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Dec 6;38(4):1149–1162. doi: 10.1093/nar/gkp1131

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2009. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 6. — WRN stimulates pol δ independently of its helicase or exonuclease activities. (A) Reactions contained pol δ/PCNA alone or with, wild-type WRN, or exonuclease-dead WRN (X-WRN) as indicated and ATPγS was included, as shown, to inhibit helicase function. Reactions proceeded for 2, 10 and 30 mins and contained 100 fmol template DNA, 2 pmol pol δ and 100 fmol WRN or X-WRN, as indicated. (B) Replication extension by WRN fragments. 1, GST control, 2. WRN_500–946, or 3. WRN_949–1432 were added (100 fmol) to pol δ/PCNA reactions. Gels in ‘B’ are cropped prior to the start of the fragile site sequence. Dashed lines: boundary of CFS insert.