Table 2.
Summary of inhibitory sequence motifs identified in FRA16D
| Inhibition observedb |
||||
|---|---|---|---|---|
| Region | Sequence | pol α | pol δ | Cell Extracts |
| 2 | GTCG(X)10CGAC | −/+ | −/+ | −/− |
| TTGXGAA(X)5TTCXCAA | −/+ | −/+ | −/− | |
| CGGT(X)3ACCG | +/+ | +/+ | −/− | |
| CACT(X)5GGTG | +/+ | +/+ | −/− | |
| 3 | [A]28 (peak c)a | +/+ | +/+ | +/− |
| [TA]23i (peak b) | +/+ | +/+ | +/+ | |
| hairpin cluster (peak a) | +/+ | +/+ | +/− | |
| 4 | [A]19 (peak d) | +/+ | +/+ | −/+ |
| Long IR (peak e) | +/+ | −/+ | −/+ | |
| GC(X)5GC | −/+ | −/+ | −/− | |
aPeaks refer to motifs indicated in Supplementary Figure S1.
b−/+ refer to inbition in complementary strands A/B.