Table 4.

Median regressions for oxygen exposure in the prediction of elevated levels of cytokines, adjusting for covariates.

	p-value§	Parameter estimate (95% CI)**	Significant covariates*
MMP 9 – 1 day	0.80	19512 (−199921, 209885)	GA
MMP 9 – 3 day	0.20	−117004 (−325486, 12894)	GA, gender, RDS
MCP-1 – 3 day	0.003	471 (173 – 890)	GA
MIP-1β – 1 day	0.10	85 (−22, 217)	EOS
MIP-1β – 3 day	0.47	−30 (−98, 56)	Apgar5, EOS
RANTES – 3 day	0.18	−5836 (−19243, 2406)	none

^§P-values from likelihood ratio tests.

^**The parameter estimate can be interpreted as the adjusted median difference in plasma levels between the two comparison groups (for example, 3 day MCP level for the oxygen exposed group is on average 471 pg/ml higher than that for the non-exposed group, after adjusting for covariates)

^*Covariates included: gestational age, gender, 5 minute Apgar < 5, any ANS (including infants who received ANS but did not have a complete course), severity of RDS (defined as > 2 doses of surfactant or any high frequency ventilation HFV vs. ≤ 2 doses of surfactant and no HFV) and early onset sepsis (EOS).