Table 3.

A comparison of fold changes (baseline versus post-treatment) in genes in naproxen-treated patients between the ulcer and the non-ulcer populations. Tissue samples were obtained from normal-appearing antral mucosa. The 5/23 genes are presented for which significant differences between the ulcer and non-ulcer groups were observed. In one non-ulcer patient, RNA degradation in the post-endoscopy specimen prevented analysis of gene expression, and this patient was excluded from the analysis.

Gene	Ulcer (N = 7)	No Ulcer (N = 17)	Placebo (N=4)
Hepatocyte Growth Factor	−2.2 (0.3)	8.2 (2.6)	−0.9 (0.7)
Cyclo-oxygenase 1	0.0 (0.7)	9.8 (2.4)	0.3 (0.8)
Toll-Like Receptor-4	−0.8 (1.0)	14.0 (2.2)	−0.2 (1.4)
Cyclo-oxygenase-2	2.3 (1.7)	−10.8 (2.2)	−0.7 (1.2)
Interleukin-8	33.5 (18.5)	−7.7 (3.2)	−1.8 (1.1)

Data are expressed as mean (SEM). P= 0.042 by Wilcoxon matched pairs signed ranks test.