Fig. 4.

Effect of L-FABP gene ablation and high-fat diet on serum β-hydroxybutyrate levels. At the end of the dietary study, serum was collected and levels of β-hydroxybutyrate were determined for male (a) and female (b) WT and L-FABP KO mice as described in “Materials and Methods”. Cross-hatched and solid bars refer to WT and KO mice, respectively. Values represent the mean ± sem, n = 5–7. Statistical analysis was as follows: * p ≤ 0.03 versus WT mice on control-diet; @ p ≤ 0.002 versus L-FABP KO mice on control-diet; ^ p ≤ 0.007 versus WT mice on high-fat diet; and # p ≤ 0.05 versus male L-FABP KO mice on high-fat diet