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. 2010 Feb 16;123(6):861–870. doi: 10.1242/jcs.060475

Fig. 7.

Fig. 7.

Proposed mechanism of GSK-3β modulation of Bif-1-dependent autophagy and cell death. Blue: under serum starvation conditions, GSK-3β maintains a limited autophagic response for cell survival by modulating the level of Bif-1 protein. Red: once GSK-3β activity is suppressed, Bif-1 protein is increased, resulting in a massive autophagy response and necrotic cell death. Green: if autophagy is blocked, the cell death route is redirected to apoptotic cell death through a mechanism associated with Bif-1-dependent Bax activation.