Table 1.
Novel Genetic variants in selected miRNA genes in ovarian cancer patients
| miRNA genes | Nt Change | Location | Allele frequency | Selected target genes (examples)* |
|---|---|---|---|---|
| miR -17 | C/T | Pri-miRNA | 0.012 | BRCA1, PTEN, p53 and ATM |
| hsa-mir-191 | C/T | Pri-miRNA | 0.006 | IGF1R, FANCC, FANCF, FANCD2, MLH3 |
| C/G | pri-miRNA | 0.012 | ||
| C/A | Pre-miRNA | 0.006 | ||
| hsa-mir-29b-2 | C/T | pri-miRNA | 0.042 | DNMT3A, IGFI, CCND2, BCL2 |
| A/T | pre-miRNA | 0.021 | DNMT3A, IGFI, CCND2, BCL2 | |
| hsa-mir-188 | T/C | pri-miRNA | 0.006 | CCND2, XRCC2, IGFI, E2F |
* This non-inclusive list shows only the potential targets known to be involved in tumorigenesis. Other, unrelated, targets may exist for these miRNAs.