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. 2010 Feb 19;2:5. doi: 10.1186/2040-2384-2-5

Figure 3.

Figure 3

Isobologram analysis indicating a lack of synergy of naltrexone with temsirolimus on VEGF-induced human EC proliferation and migration. Panel A: Isobologram analysis of the combination of naltrexone and temsirolimus on inhibition of VEGF-induced proliferation. The dashed line indicates a zero interaction for the isobole. The close proximity of the data with the dashed line indicates there is not a synergistic interaction. Panel B: Isobologram analysis of the combination of naltrexone and temsirolimus on inhibition of VEGF-induced migration. The dashed line indicates a zero interaction for the isobole. The close proximity of the data with the dashed line indicates there is not a synergistic interaction.