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Atrap deficiency causes low urinary pH and enhances renal carboanhydrase inhibitor sensitivity. (Top) Urinary pH of Atrap−/− (n = 40) and Atrap+/+ (n = 36) under ambient conditions and after the application of the carboanhydrase inhibitor acetazolamide (40 μg/g body wt; n = 20 for each genotype). (Bottom) Urine volume collected during a period of 120 minutes after application of acetazolamide in Atrap−/− (n = 20) and wild-type mice (n = 20).
