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GSK3β gene deletion reduced dDAVP-induced urine-concentrating capacity in mice. (a) WT and KO mice were injected with dDAVP (1 μM/kg body wt; intraperitoneally) and spot urine collected. *P < 0.001; n = 8. (b) Δ change in urine osmolality of dDAVP-treated mice compared with basal level. (c) pS256-AQP2 levels in the inner medulla and papilla of WT and KO mice 1 hour after dDAVP treatment. @P < 0.01.
