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GSK3 inhibition reduced cAMP generation in WT C57BL/6J mice and cultured IMCD3 cells. cAMP levels in response to dDAVP (1 μM) or forskolin (1 μM) were measured in the renal papillae of normal C57BL/6J mice (A) or IMCD cells (B) pretreated with vehicle or SB216763 (5 μM). Mice n = 7; IMCD cells n = 6. @P < 0.01; *P < 0.001 vehicle versus SB216763.
