Table 3.
Levels of HMGB1, LBP, IL-6 and CRP in infected children without SIRS, with sepsis and with severe sepsis.
| Biomarker | Infected patients without SIRS (n = 36) |
Sepsis patients (n = 91) |
Severe sepsis patients (n = 13) |
p-valuea |
|---|---|---|---|---|
| HMGB1 (ng/ml) | ||||
| Median | 2.5 | 3.0 | 3.1 | NS |
| IQR | 0.3-5.9 | 1.0-7.3 | 1.3-14.3 | |
| p-valueb | NS | NS | ||
| Lipopolysaccharide--binding protein (μg/ml) | ||||
| Median | 14.7 | 26.4 | 79.7 | < 0.001 |
| IQR | 8.7-26.0 | 17.5-42.2 | 57.8-90.6 | |
| p-value | < 0.001 | < 0.001 | ||
| Interleukin 6 (pg/ml) | ||||
| Median | 8.9 | 32.1 | 290.0 | < 0.001 |
| IQR | 4.0--18.8 | 13.8-68.1 | 67.9-522.6 | |
| p-valueb | < 0.001 | < 0.001 | ||
| C-reactive protein (mg/l) | ||||
| Median | 12.0 | 63.0 | 211.8 | < 0.001 |
| IQR | 3.1-36.6 | 27.0-114.5 | 108.0-318.6 | |
| p-valueb | < 0.001 | < 0.001 |
Data presented as median and interquartile range (IQR). SIRS, systemic inflammatory response syndrome. HMGB1, high mobility box-1 protein; LBP, lipopolysaccharide-binding proteine; IL-6, interleukine-6; CRP, C-reactive protein. NS, not significant. aKruskal-Wallis tests. b Mann Whitney two independent sample tests, compared with the previous group in the table.