Table 2.
Physiologic parameters used in the child-specific PBPK model.
| Participant ID | Age (years)a | BW (kg) | Normalized cardiac output (L/H)b | Normalized alveolar ventilation rate (L/H)b |
|---|---|---|---|---|
| R1 | 4 | 15.5 | 23.94 | 14.24 |
| R2 | 4 | 21.4 | 18.8 | 11.18 |
| R3 | 4 | 14.5 | 25.17 | 14.98 |
| R4 | 5 | 16.8 | 26.17 | 15.56 |
| R5 | 3 | 13.4 | 22.1 | 13.34 |
| R6 | 5 | 19.6c | 23.31 | 13.86 |
| S1 | 4 | 17.3 | 22.04 | 14.3 |
| S2 | 6 | 18.2 | 27.83 | 16.68 |
| S3 | 3 | 15 | 20.31 | 12.25 |
| S4 | 4 | 15.5 | 23.94 | 14.98 |
| S5 | 5 | 16.8 | 26.17 | 15.56 |
| S6 | 6 | 22.7 | 23.58 | 14.14 |
| S7 | 3 | 14.5 | 20.83 | 12.57 |
a
Age rounded up to a whole year.
b
Equations in Price et al. (2003) were used to calculate rates of cardiac output and alveolar ventilation; results were divided by BW3/4.
c
Study participant did not provide a BW; value taken from Exposure Factors Handbook, Table 11–3 (U.S. EPA 2002b).