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. 2010 Mar 4;5(3):e9522. doi: 10.1371/journal.pone.0009522

Figure 4. Model predictions for Hog1 phosphorylation response to step increase of 0.4 M NaCl in different mutants.

Figure 4

(A) Hog1 catalytically inactive mutant (Hog1K52R), In the model, we set ks1_Glyc = 0 for this mutant. (B) Knockout of cytoplasmic protein tyrosine phosphatase Ptp3 (ptp3 Δ). In the model, we set kdepho_Hog1PPc = 0 for this mutant. (C) Knockout of nuclear protein tyrosine phosphatase Ptp2 (ptp2Δ). In the model, we set kdepho_Hog1PPn = 0 for this mutant. (D) Knockouts of Ptp2 and Ptp3 (ptp2Δ, ptp3 Δ). In the model, we set kdepho_Hog1PPc = 0 and Kdepho_Hog1PPn = 0 for this mutant.