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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Acta Neuropathol. 2009 Oct 30;119(3):365–374. doi: 10.1007/s00401-009-0605-1

Figure 3. FTLD-TDP microscopic pathology.

Figure 3

Ubiquitin (Ub) and TDP-43 immunoreactive inclusions including neuronal cytoplasmic inclusions (NCIs), dystrophic neurites (DNs), glial cytoplasmic inclusions (GCIs) and neuronal intranuclear inclusions (NIIs) were most similar to FTLD-TDP Type 1 (Mackenzie et al(26)). (a-d) In frontal and parietal cortex, short DNs and numerous small, round or comma-shaped NCIs in superficial layers predominated. (e-h) At higher magnification, note NCIs in pre-supplementary motor cortex (preSMA) and a lentiform NII (g) in right angular gyrus (ANG). (i) Inclusions immunopositive for TDP-43 or ubiquitin (not shown) were not observed in the dentate gyrus. Scale bar in (h) represents 20 uM and applies to (e), (f) and (h). Scale bar in (i) represents 10 um in (g), 20 um in (a-d) and 50 um in (i).