Table 2.
Semi-quantitative ratings of microvacuolation, gliosis, and ubiquitin and TDP-43 pathology.
| H & E | Ubiquitin | TDP-43 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| L/R Microvacuolation | L/R Gliosis | L/R NIIs | L/R NCIs | L/R DNs | L/R GCIs | L/R Dots/threads | L/R NIIs | L/R NCIs | L/R DNs | L/R GCIs | L/R dots/threads | |
| aMCC | ++/++ | ++/++ | 0/0 | ++/++ | +/+ | 0/0 | ++/+++ | 0/0 | +/+++ | +/+++ | 0/+ | ++/0 |
| Middle insula | +/++ | ++/++ | 0/0 | +/+++ | ++/+++ | +/+ | +/0 | 0/0 | ++/+++ | ++/++ | +/+ | 0/0 |
| Pre-SMA | ++/+++ | ++/+++ | +/0 | ++/+++ | ++/++ | +/0 | +++/+++ | +/0 | +++/++ | ++/+++ | +/+ | +++/+ |
| Precentral gyrus | ++/+++ | ++/+++ | 0/0 | ++/++ | ++/+ | +/0 | ++/++ | 0/0 | ++/++ | +++/+ | +/+ | +/0 |
| Angular gyrus | 0/+ | +/++ | +/0 | +/++ | +/+ | 0/0 | ++/++ | +/0 | +/++ | +/++ | 0/+ | ++/0 |
| Claustrum | NA | +/+ | 0/0 | 0/+ | +/+ | 0/0 | +/0 | 0/0 | +/++ | ++/+ | 0/0 | 0/0 |
| Putamen | NA | +++/+++ | 0/0 | +/+ | ++/+ | 0/0 | +/+ | 0/0 | +/+ | ++/+ | 0/0 | ++/+ |
| Globus pallidus | NA | +/0 | 0/0 | 0/0 | 0/0 | 0/0 | +/0 | 0/0 | 0/+ | +/+ | 0/+ | +/0 |
| Entorhinal cortex | 0/0 | 0/0 | 0/0 | 0/0 | +/+ | 0/0 | +/+ | 0/0 | 0/0 | 0/+ | 0/0 | 0/0 |
| Dentate gyrus | N/A | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
| CA3-4 | N/A | 0/-- | 0/-- | 0/-- | 0/-- | 0/-- | +/-- | 0/-- | 0/-- | 0/-- | 0/-- | 0/-- |
| CA2 | N/A | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 |
| CA1/subiculum | N/A | 0/0 | 0/0 | 0/0 | 0/0 | 0/0 | +/0 | 0/0 | 0/0 | 0/+ | 0/0 | 0/0 |
H & E = Hematoxylin and eosin, Ub = Ubiquitin, TDP-43 = TAR DNA-binding protein 43, L/R = Left/Right, NCIs = Neuronal cytoplasmic inclusions, DNs = Dystrophic neurites, GCIs = Glial cytoplasmic inclusions, NIIs = Neuronal intranuclear inclusions, aMCC = anterior midcingulate cortex, PCg = Postcentral gyrus, EntoRC/PeriRC = Entorhinal/perirhinal cortex, Ub = Ubiquitin, SMA = Supplementary motor area, NA = Not assessed. 0 = NSPA, + = mild, ++ = moderate, +++ = severe, -- = region damaged/not available.