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. 2010 Mar;176(3):1122–1129. doi: 10.2353/ajpath.2010.090733

Figure 3.

Figure 3

Subcutaneous lipid deposition, which is characteristic of human lymphedema, is present in the Chy mouse but not the K14-VEGFR-3-Ig mouse. A: Oil red O staining reveals the lipid accumulation, as compared with wild-type, in the hypodermis of Chy mice (top). K14-VEGFR-3-Ig mice (bottom) did not appear to have significant lipid accumulation. Bar = 200 μm. B: Total tissue lipids extracted from tail dermis quantitatively demonstrate the increase in lipid accumulation within the Chy mouse tail (*P = 0.034) and a quantified decrease in lipids in the K14-VEGFR-3-Ig mouse as compared with their control strains (“WT”; **P = 0.013).