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. 2010 Mar;176(3):1139–1147. doi: 10.2353/ajpath.2010.090459

Figure 1.

Figure 1

Regulation of profibrotic TGF-β transcriptional targets by BMP-7. A–C: qRT-PCR analysis shows expression of profibrotic TGF-β-inducible genes in PTCs after 24 hours with or without1 ng/ml TGF-β incubation with or without 50 ng/ml BMP-7. A: TGF-β. B: Connective tissue growth factor (CTGF). C: PAI-1. D: PAI-1 expression after 8 days of culture with or without 1 ng/ml TGF-β with or without 50 ng/ml BMP-7. n = 3, mean of duplicate determinations. Error bars indicate +SEM. Representative data from one of three experiments giving similar results. *P < 0.01 versus control. **P < 0.05 versus TGF-β.