Figure 4.

Fibrotic repair. Representative images of Sirius red-stained liver sections (A) derived from injured and repairing animals treated with either saline or RP3 (×40) illustrate the data shown in the bar graph. Collagen (B) is expressed as a percentage of total area section area. Biliary obstruction significantly (*P ≤ 0.05) increased the deposition of collagen both in saline- and RP3-treated groups following 7 days of injury. Collagen content, as measured by Sirius red, was significantly (*P ≤ 0.05) decreased in the saline-treated animals following decompression (day 2). RP3 treatment blocked the decompression related decline in collagen. Measures of collagen content were not different from injured animals and significantly (**P ≤ 0.05) elevated when compared with saline-treated matched controls.