Figure 2.

PbA infection leads to decreased blood flow in pial vessels. Arteriolar (A) and venular (B) blood flow in PbA-infected mice with or without CM and in uninfected control mice. Results are expressed as the percentage change in relation to baseline measurements performed before infection. Flow was significantly decreased on day 6 in mice that developed CM (arteriolar: P = 0.0003; venular: P = 0.0003). Data are the mean ± SEM. C: Arteriolar blood flow in mice with CM, at the time of presentation of clinical signs (irrespective of the day of infection). Flow was significantly decreased in mice with CM (P < 0.0001). Values shown for uninfected controls mice, and infected mice without CM are the lowest recorded for each mouse on days 5 to 8. Bars indicate the mean value.