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. 2010 Mar;176(3):1377–1389. doi: 10.2353/ajpath.2010.090849

Figure 6.

Figure 6

Rare lesions in CFTR−/− liver and incidental findings in all genotypes. A: Infrequent to rare findings in CFTR−/− liver. Biliary tracts had expansive and florid proliferation (arrow, top left panel, MT stain) with adjacent fibrosis (blue) and inflammation. Intrahepatic ducts had mucinous change (arrow, top right panel, PAS stain), mucocellular plugs (arrow, left bottom panel, HE stain), or choleliths (arrows, right bottom panel, HE stain). Scale bars = 55 μm. B: Widespread bridging (arrowheads) of triads by biliary hyperplasia, inflammation, and fibrosis (blue staining) was rarely detected in CFTR−/− pigs. Scale bars = 220 μm. In these cases, the serosal surface was often retracted causing a slightly irregular surface (arrows, inset, Scale bars = 197 μm). MT stain. C: Foci of extramedullary hematopoiesis were composed of erythroid, granulocytic, and megakaryocytic lineage aggregates (respective panels) in liver of all genotypes. HE stain. Scale bars = 17.5 μm.