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Complete absence of MCP-1/CCL2 increases muscle strength in PMP22tg mice. Muscle (grip) strength of hindlimbs of wild-type and PMP22 mutants at the age of six months. PMP22tg/MCP-1+/+ mice show an impaired muscle strength compared with PMP22wt/MCP-1+/+ mutants, whereas PMP22tg/MCP-1−/− mice exhibit an improvement of grip strength to a level similar to that of PMP22wt/MCP-1+/+ mice. Each indicated value represents a tested individual. *P < 0.05, ***P < 0.001, Student t test.
