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. 2010 Mar;176(3):1390–1399. doi: 10.2353/ajpath.2010.090694

Figure 7.

Figure 7

Increased MCP-1/CCL2-expression in peripheral nerves of PMP22tg mice is mediated by the MEK1/2/ERK1/2 signaling cascade. In vivo inhibition of the MEK1/2/ERK1/2 cascade and MCP-1/CCL2-expression by daily treatment with CI-1040 for three weeks. A: Western blot analyses and the corresponding densitometric measurement of femoral quadriceps nerve lysates of CI-1040 and sham-treated mice at the age of two months. Data are shown as a mean value of two experiments with three to five mice in each group. Note the decreased phosphorylation of ERK1/2 (44/42 kDa) in nerves of mice with daily CI-1040 injection. B: MCP-1/CCL2 mRNA is reduced in nerves of CI-1040–treated PMP22tg mice in comparison with sham-treated mutants. Treatment of wild-type mice does not significantly change the MCP-1/CCL2-expression. *P < 0.05, Student t test, **P < 0.01.