Figure 2.

Human HSD17B1 expression enhances uterine response to weak estrogen estrone. Estrogen action was enhanced in the presence of E1 in HSD17B1TG uterus as indicated by the fact that the uterus weight of HSD17B1TG females increased more with a small dose of E1 than the weight of wild-type uterus. The different growth response was observed in the weights both by including (A) and excluding (B) the uterine secretory products, ie, full and empty uterus, respectively. Macroscopic images (C) of wild-type and HSD17B1TG uteri treated with placebo, and with equal dose of E1 (1 μg/kg/d) and E2 (50 μg/kg/d). E1 = estrone, E2 = estradiol, Pla = placebo, *P < 0.05, ***P < 0.001.