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. 2010 Mar;176(3):1494–1504. doi: 10.2353/ajpath.2010.090655

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© 2010 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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A spontaneous neovascularization in ADAMTS9^+/− corneas. A: Age-dependent incidence of corneal neovascularization in ADAMTS9^+/− mice. B: Photographs of eyes from mature ADAMTS9^+/− mice showing corneal neovascularization. C: H&E-stained section of ADAMTS9^+/− cornea showing capillaries with β-gal+ lining cells (arrows, blue) in the corneal stroma. D: Combined β-gal histochemistry (blue) and PECAM-1 immunohistochemistry (red) of an ADAMTS9^+/− cornea with vascularization shows that β-gal+ cells (arrows) in corneal stroma are endothelial cells. Scale bars: 11 μm (left) and 6 μm (right).