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. 2010 Mar;176(3):1494–1504. doi: 10.2353/ajpath.2010.090655

Figure 4.

Figure 4

Knockdown of ADAMTS9 in human microvascular EC leads to enhanced tube formation on Matrigel. A: RT-PCR showing expression of ADAMTS9 mRNA in HBMECs and successful knockdown with siRNA. B: Quantitative analysis of the length of tube-like structures measured under the indicated conditions and shown as a percentage of the control. *P < 0.001. C: Representative phase-contrast photomicrographs of tube-like structures formed under the indicated conditions. Corresponding data for microvascular ECs from human heart and dermis and human umbilical vein EC are presented in Supplemental Figure 2 at http://ajp.amjpathol.org.