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. 2010 Mar;176(3):1494–1504. doi: 10.2353/ajpath.2010.090655

Figure 5.

Figure 5

Enhanced spreading, decreased adhesion, and increased migration of HBMECs on ADAMTS9 knockdown. A: Effect of ADAMTS9 siRNA on cell spreading was evaluated in HBMECs permitted to attach to an uncoated or Matrigel-coated substrate. The arrows indicate filopodia, which were not seen in control siRNA-treated cells at this time point. B: Comparison of the effect of ADAMTS9 siRNA and control siRNA on cell attachment to fibronectin (FN), vitronectin (VN), laminin (LN), and collagen IV (Col). *P < 0.001. C: Enhanced migration of microvascular endothelial cells on ADAMTS9 knockdown. A representative example of three independent experiments is illustrated on the left. The panel at right shows quantitative analysis of three independent migration assays.