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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Dev Biol. 2009 May 9;332(1):104–115. doi: 10.1016/j.ydbio.2009.05.541

Figure 6. E2F-target genes and Dppa5 expression are deregulated in Rb and Rb;Ef24 mutant placentas.

Figure 6

A) Cell cycle genes are expressed at increased levels in E13.5 Rb−/− placentas compared to wild-type placentas. B) At E11.5, wild-type and mutant placentas express cell cycle genes at similar levels. Expression of Eomes (a trophoblast stem cell marker) and Dppa5 (a pluripotency marker) in wild-type and mutant placentas at E13.5 (C) and E11.5 (D). Eomes is expressed at similar levels among the various genotypes whilst Dppa5 expression is significantly elevated in Rb−/− and Rb−/−;E2f4−/− placentas. Gene expression levels are normalized to ubiquitin expression levels and error bars represent standard deviation.