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Conditional mutation of Rb allows survival of cRb−/−;E2f4−/− embryos up to E18.5.
| Total # | cRb−/−;E2f4+/+ | cRb−/−;E2f4+/− | cRb−/−;E2f4−/− | |
|---|---|---|---|---|
| Age | Embryos | obs exp | obs exp | obs exp |
| E18.5 | 258 | 19 16 | 39 32 | 12 16 |
| E15.5 | 100 | 6 6 | 15 12 | 4 6 |
| E13.5 | 65 | 6 4 | 9 8 | 5 4 |
Frequency of embryos arising from Rbc/c;E2f4+/− × cRb+/−;E2f4+/−;Meox2+/cre intercrosses. Only Meox2+/cre embryos shown. Obs=observed number, exp=expected number.
