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High-dose DA attenuates NMDA-EPSCs through activation of D2, but not D1, receptors. A, Coapplication of selective D2 receptor antagonist L741,626 (10 μm) with DA (200 μm) significantly abolished DA-induced attenuation of NMDA-EPSCs (n = 6; p < 0.01). B, On the contrary, coapplication of selective D1 receptor antagonist SCH 23390 (10 μm) with DA (200 μm) potentiated DA-induced attenuation of NMDA-EPSCs (n = 6; p < 0.05). *p < 0.05; **p < 0.01 for all figures. Error bars indicate SEM.
