. 2010 Mar;74(1):95–120. doi: 10.1128/MMBR.00042-09

TABLE 1.

Alkali metal cation transporters in S. cerevisiae

Name	ORF	YETI no.^a	Localization^b	Transporter type	Length (aa)	No. of TMS	Substrate specificity^c	Main function	Reference
Trk1	YJL129c	2.A.38.2.1	PM	Uniporter	1,235	12	K⁺, Rb⁺	K⁺ uptake	82
Trk2	YKR050w	2.A.38.2.1	PM	Uniporter	889	12	K⁺, Rb⁺	K⁺ uptake	128
Tok1	YJL093c	1.A.1.7.1	PM	Channel	691	10	K⁺	K⁺ efflux	116
Ena1	YDR040c	3.A.3.9.1	PM	ATPase	1,091	10	Na⁺, Li⁺, K⁺, Rb⁺	Detoxification	102
Nha1	YLR138w	2.A.36.4.1	PM	Antiporter	985	12	K⁺, Na⁺, Li⁺, Rb⁺	K⁺ efflux	219
Pho89	YBR296c	2.A.20.2.2	PM	Symporter	574	10	Na⁺, P_i	P_i uptake	156
NSC1	Not known		PM	Channel	Not known	Not known	Monovalent + bivalent cations	Not known	30
Kha1	YJL094c	2.A.37.4.1	GA	Antiporter	873	12	K⁺, Li⁺, Na⁺	Detoxification	153
Nhx1	YDR456w	2.A.36.2.1	LE	Antiporter	633	8 (?)	Na⁺, Rb⁺, K⁺, Li⁺	Detoxification, vesicle trafficking	185
Vnx1	YNL321w	2.A.19.Y1.Z1	VAC	Antiporter	908	13	Na⁺, K⁺	Detoxification	37

YETI, Yeast Transporter Information (55, 56), based on Transport Classification (TC) system (248).

PM, plasma membrane; GA, Golgi apparatus; LE, late endosomes; VAC, vacuole.

Bold, preferred substrate; italic, substrate predicted from phenotypic observations.