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Model of OM vesicle production. Shown is the budding of the Gram-negative bacterial envelope. Released OM vesicles contain periplasmic material and OM proteins and lipids, including PAMPs and other virulence factors, as described in the text. Although details of the mechanism remain unclear, budding is thought to occur in places where lipoprotein links between the OM and the peptidoglycan are broken or missing.
