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Model for pre-IC formation. In this model, interacting DUE-B, Cdc45, and TopBP1 associate with the pre-RC. Cdk2 phosphorylation triggers Cdc45 activation of the pre-IC. Upon origin unwinding, DUE-B is released, and RPA binds to the origin, followed by replisome assembly and DNA synthesis. See the text for further details.
