TABLE 2.
Genes encoding cell envelope,a ribosomal, and amino acid biosynthetic proteins
| Gene or operon | Fold change in expression relative to SL1344b |
||
|---|---|---|---|
| L133 | L786 | L1007 | |
| Multidrug transporters/regulators | |||
| acrA | - | 8.66 | 3.36 |
| acrB | - | 8.19 | 2.13 |
| acrE | - | 2.47 | - |
| acrF | - | 3.00 | - |
| tolC | - | 5.16 | 3.35 |
| ompA | - | - | 1.43 |
| ompC | 0.46 | - | - |
| ompF | - | 0.21 | - |
| ompX | 0.61 | - | - |
| ramA | - | 144.32 | 25.04 |
| ramR | 0.21 | 0.39 | - |
| rpoD | 1.36 | - | - |
| Ribosomal biosynthesis | |||
| rplA/B | 1.98/1.65 | - | - |
| rplD-F | 1.44-1.84 | - | - |
| rplK-M | 1.74-2.04 | - | - |
| rplR | 2.33 | - | - |
| rplU | 1.80 | - | - |
| rplW | 1.82 | - | - |
| rpsA | 2.15 | - | - |
| rpsF | 1.97 | - | - |
| rpsH | 2.05 | - | - |
| rpsJ | 1.95 | - | - |
| rpsL | 2.08 | - | - |
| rpsR | 2.01 | - | - |
| Amino acid biosynthesis | |||
| argA/B | 4.29/7.32 | - | - |
| argD | 12.09 | - | - |
| argG/H | 8.88/5.94 | - | - |
| argR | 4.16 | - | - |
| aroA | 0.47 | - | - |
| aroH | 0.16 | - | - |
| artI/J | 2.42/12.99 | - | - |
| artP | 3.25 | - | - |
| cysC | - | - | 0.42 |
| cysD | 11.32 | - | 0.25 |
| cysG | 3.75 | - | - |
| cysH | - | - | 0.53 |
| cysJ | 2.93 | - | 0.37 |
| cysK | 0.43 | - | 0.47 |
| cysN | 2.81 | - | 0.38 |
| cysP | 12.60 | - | - |
| hisA-D | 0.17-0.23 | - | - |
| hisF-I | 0.20-0.23 | - | - |
| hisQ | 2.72 | - | - |
| ilvC | 0.42 | - | - |
| ilvE | 0.64 | - | - |
| ilvI | 0.53 | - | - |
| ilvM | 0.54 | - | - |
| trpB | 0.11 | - | - |
| trpS2 | 0.04 | - | - |
a
Genes relevant to antibiotic transport and regulation thereof with significantly (B > 0) different expression compared with SL1344.
b
-, no significant change in expression.