Skip to main content
. 2010 Jan 14;192(6):1573–1585. doi: 10.1128/JB.01394-09

FIG. 1.

FIG. 1.

Intermediates in carbon metabolism and CcpA and CodY regulation and CodY-independent stringent control of the genes involved in this metabolism. The glucose and pyruvate metabolism described in the text includes glycolysis; the formation of acetyl-CoA, oxaloacetate, and alanine; the secretory pathways for acetoin, acetate, and lactate; and the synthesis of branched-chain amino acids. CcpA-N and CcpA-P indicate negative and positive regulation by CcpA, respectively, and CodY-N and CodY-P indicate negative and positive regulation by CodY, respectively. The ilv-leu (40) and citB (16) genes are known to be repressed by CodY, whereas the ackA gene is activated (39). Also, the citZ gene is repressed by CcpA (17), whereas the ilv-leu (41, 49), alsSD (51), pta (33), and ackA (50) genes are activated by CcpA. SC-N and SC-P indicate negative and positive CodY-independent stringent control, respectively. Abbreviations: TCA, tricarboxylic acid; G6P, glucose-6-phosphate; F6P, fructose-6-phosphate; FBP, fructose-1,6-bisphosphate; DHAP, dihydroxyacetone phosphate; GAP, glyceraldehyde 3-phosphate; PEP, phosphoenolpyruvate.