Table V.
Association of PTGS2 SNPs with prostate cancer in the BPC3
| SNP | Casesa | Controlsa | OR (99% CI)b | Ptrendc | Gene-adjusted Ptrendd |
| rs10911902 | |||||
| CC | 5626 | 6072 | 1.00 | 0.57 | >0.80 |
| CT | 2138 | 2232 | 1.02 (0.93–1.12) | ||
| TT | 213 | 261 | 0.85 (0.67–1.10) | ||
| rs4648298 | |||||
| TT | 7597 | 8100 | 1.00 | 0.25 | >0.80 |
| TC | 342 | 420 | 0.92 (0.75–1.10) | ||
| CC | 7 | 13 | 0.80 (0.22–2.54) | ||
| rs2206593 | |||||
| GG | 7189 | 7692 | 1.00 | 0.34 | >0.80 |
| GA | 788 | 872 | 0.95 (0.83–1.09) | ||
| AA | 24 | 29 | 0.90 (0.43–1.82) | ||
| rs5275 | |||||
| AA | 3419 | 3664 | 1.00 | 0.44 | >0.80 |
| AG | 3465 | 3709 | 1.02 (0.93–1.11) | ||
| GG | 1006 | 1092 | 1.04 (0.91–1.19) | ||
| rs5277 | |||||
| CC | 3674 | 3962 | 1.00 | 0.27 | >0.80 |
| CG | 927 | 1088 | 0.95 (0.83–1.09) | ||
| GG | 80 | 103 | 0.91 (0.62–1.36) | ||
| rs4648261 | |||||
| CC | 6501 | 7058 | 1.00 | 0.42 | >0.80 |
| CT | 266 | 307 | 0.97 (0.78–1.22) | ||
| TT | 3 | 10 | 0.32 (0.06–1.84) | ||
| rs2745557 | |||||
| GG | 5614 | 5954 | 1.00 | 0.43 | >0.80 |
| GA | 2098 | 2338 | 0.96 (0.87–1.05) | ||
| AA | 229 | 235 | 1.03 (0.80–1.31) | ||
| rs20417 | |||||
| CC | 5561 | 5999 | 1.00 | 0.13 | >0.80 |
| CG | 2155 | 2299 | 1.05 (0.95–1.14) | ||
| GG | 259 | 268 | 1.10 (0.88–1.41) | ||
| rs689466 | |||||
| TT | 5089 | 5530 | 1.00 | 0.62 | >0.80 |
| TC | 2493 | 2652 | 1.00 (0.92–1.09) | ||
| CC | 403 | 398 | 1.06 (0.88–1.29) | ||
| rs12042763 | |||||
| GG | 4595 | 4878 | 1.00 | 0.54 | >0.80 |
| GT | 2802 | 3071 | 0.96 (0.88–1.05) | ||
| TT | 487 | 498 | 1.02 (0.86–1.22) | ||
| rs7550380 | |||||
| GG | 2847 | 2916 | 1.00 | 0.16 | >0.80 |
| GT | 1035 | 1082 | 1.06 (0.92–1.21) | ||
| TT | 112 | 129 | 1.16 (0.81–1.64) | ||
| rs2383529 | |||||
| AA | 4686 | 5050 | 1.00 | 0.13 | >0.80 |
| AG | 2709 | 2900 | 1.04 (0.95–1.13) | ||
| GG | 550 | 589 | 1.09 (0.92–1.30) |
a
Numbers may not add up to 100% of subjects due to genotyping failure.
b
Unconditional logistic regression adjusted for age at diagnosis/selection as control (in five year intervals), study and ethnicity.
c
P-value for trend before adjustment for multiple testing.
d
P-value for trend after adjustment for multiple testing at the gene level.